Ferroptosis and Intrinsic Drug-induced Liver Injury by Acetaminophen and Other Drugs: A Critical Evaluation and Historical Perspective. (PubMed, J Clin Transl Hepatol) - Dec 9, 2024 - "More recently, ferroptosis-a novel, non-apoptotic form of cell death-was identified in NRAS-mutant HT-1080 fibrosarcoma cells exposed to erastin and other NRLs...Overall, the published data support the idea that multi-layered endogenous antioxidant defense mechanisms in the liver limit the occurrence of pathophysiologically relevant LPO under normal conditions. Only when these defense mechanisms are severely compromised does ferroptosis become a significant mode of drug-induced cell death."
Journal • Review • Fibrosarcoma • Hepatology • Liver Failure • Oncology • Sarcoma • Solid Tumor • GPX4
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Anup Ramachandran; Hartmut Jaeschke
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