Monocytic Leukemia Cell Resistance to Ferroptosis Is Overcome By Iron Chelation (ASH 2024) - Dec 7, 2024 - "Erastin is known to be largely ineffective as a ferroptosis-inducer in THP-1 cells and other leukemic cell lines.Methods : THP-1 cells were cultured in various concentrations of ferric citrate or deferoxamine (DFO) for 96 hours to simulate chronic states of iron excess and deficiency, respectively. It also provides novel evidence of ferric citrate attenuating THP-1 cell resistance to erastin and, most notably, a synergistic lethality between an iron chelator and ferroptosis-inducer (DFO and erastin). This result suggests a novel avenue of antileukemic combination therapy that has potential to combat the poor prognoses of AMoL and acute leukemias, more broadly."
Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • GPX4
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Zachariah A.H. Fenniri 1; Sarah Lane BSc 1; Juergen Ehlting BSc PhD 2, 1; Patrick B Walter PhDMSc 1
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