Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Lactate Dehydrogenase A Is a Novel Positive Regulator of Vascular Smooth Muscle Cell Ferroptosis During Aortic Dissection. (PubMed, Antioxid Redox Signal) - Nov 28, 2024 - "We focused on the key enzyme of glycolysis, lactate dehydrogenase A (LDHA), and found that LDHA overexpression promoted ferroptosis and lipid peroxidation in cystine deprivation- or imidazole ketone erastin-treated VSMCs and vice versa...Redox Signal. 00, 000-000."
Journal • AIFM2 • GPX4 • LDHA • SLC7A11

http://www.ncbi.nlm.nih.gov/pubmed/39605213

Bo Huo; Ding-Sheng Jiang; Fu-Han Gong; Hanshen Luo; Jingjie Chen; Xian Guo; Xiang Wei; Xin Feng; Xin Yi; Yue Chen; Ze-Min Fang

Nov 28, 2024