Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis. (PubMed, Biochem J) - Nov 28, 2024 - "Loss of PRDX6 resulted in increased sensitivity to erastin-induced ferroptosis, independent of selenium and GPX4, as a consequence of increased levels of lipid hydroperoxides, that reverted to normal levels upon rescue with PRDX6. The results presented demonstrate that all three enzymatic activities of PRDX6 contribute to the role of this multifunctional enzyme in diverse cellular processes, including membrane phospholipid remodeling and glycerophospholipid functional diversity, resulting in altered lipid peroxides and modulation of AA disposition and traffic. These contributions highlight the complexity of the changes that loss of PRDX6 exerts on cell functionality.."
Journal • Hepatology • Liver Cancer • Metabolic Disorders • Oncology • GPX4 • PRDX6
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Ángel Ortiz-Alcántara; Brian McDonagh; C Alicia Padilla; Daniel J Lagal; J Antonio Bárcena; José R Pedrajas; Raquel Requejo-Aguilar
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