Cascade Bilateral Regulation of Ferroptosis and Immune Activation Conducted by the Electron-Accepting-Inspired Glycopolymer-Based Nanoreactor. (PubMed, ACS Appl Mater Interfaces) - Nov 21, 2024 - "By taking advantage of the sensitivity difference between tumor cells and dendritic cells (DCs) to the ferroptosis inducer erastin (Er) based on varying xCT expression levels, we developed Er-loaded nanoparticles CNP/Er. These nanoparticles not only enhance ferroptosis in 4T1 cells through Gpx4 inhibition by CNP but also promote DC maturation by utilizing CNP's hypoxia-responsive mechanism to increase ROS levels. The CNP/Er was believed to be an ideal candidate for bilateral regulation of ferroptosis and immune activation in one nanoreactor."
Journal • Oncology • GPX4
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Fangying Yu; Haiya Lou; Hong Yuan; Shanshan Xiang; Shiyan Li; Xuwei Shang; Yihe Qiu; Zixu Wang
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