Rbbp6-Mediated Bmal1 Ubiquitination Inhibits YAP1 Signaling Pathway to Promote Ferroptosis in Diabetes-Induced Testicular Damage. (PubMed, Diabetes Metab J) - Nov 6, 2024 - "In addition, knockdown of YAP1 or treatment with ferroptosis inducer erastin blocked the above effects caused by Bmal1 overexpression. Rbbp6-mediated Bmal1 ubiquitination suppressed YAP1 pathway, promoting ferroptosis in DITD. This study highlighted Rbbp6/Bmal1/YAP1 axis as a potential therapeutic target for mitigating DITD."
Journal • Diabetes • Eye Cancer • Metabolic Disorders • Oncology • Retinal Disorders • Retinoblastoma • Solid Tumor • Targeted Protein Degradation • ARNTL • BMAL1 • GPX4 • RBBP6 • SLC7A11 • YAP1
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Bei Liu; Jun Qiao; Yuan Tian; Yuehai Xiao; Zhiqiang Zhu
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