Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

cyclophosphamide - Generic mfg.

Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis. (PubMed, Andrology) - Oct 22, 2024 - "HNG demonstrated a therapeutic effect on oligoasthenozoospermia in a mouse model by reducing oxidative stress and ferroptosis. In TM3 and TM4 cells, HNG attenuated cellular oxidative stress and inhibited ferroptosis via the Nrf2/GPX4 pathway."
Journal • Preclinical • Infertility • Sexual Disorders • GPX4

http://www.ncbi.nlm.nih.gov/pubmed/39435863

Changhong Zhu; Liping Zou; Qiwen Feng; Wei Xia; Yumeng Liu

Oct 22, 2024