Small extracellular vesicles derived from brain microvascular endothelial cells undergone cardiac arrest aggravate cerebral injury by promoting neuronal ferroptosis (EUSEM 2024) - Oct 20, 2024 - Abstract #POS0459; "In addition, CA-CPR-ROSC mice given Fer-1 and Lip-1 showed higher ROSC rates, neurological function scores, and 7-day survival rates, while, mice given RSL3 and Erastin manifested lower ROSC rates, poor neurological function and lower 7-day survival rates. Proteome sequencing indicated that there were 136 differentially expressed proteins in sEV from CPR group compared with that from sham group, of which 72 proteins were up-regulated and 64 proteins were down-regulated.CONCLUSION : In general, our results demonstrate that BMEC-sEVCPR exacerbates CIRI by facilitating ferroptosis of neurons, suggesting that targeting this mechanism may be a feasible strategy to treat CIRI following CA-CPR-ROSC."
Cardiovascular • Reperfusion Injury • ACSL4 • ANXA2 • CD63 • GPX4 • RAB27A
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mengyao jian1; Gan Lu1; Cao Yu2
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