Targeting Ferroptosis: Small-molecule Inducers as Novel Anticancer Agents. (PubMed, Anticancer Agents Med Chem) - Oct 16, 2024 - "This review consolidates insights into the molecular mechanisms underpinning ferroptosis and evaluates the therapeutic potential of small-molecule inducers, such as erastin, RSL3, sulfasalazine, and sorafenib, which selectively trigger ferroptosis in cancer cells. Additionally, comprehensive evaluations of the long-term safety and therapeutic indices of the involved compounds are imperative. Such investigations are poised to herald a transformative shift in the paradigm of oncology, paving the way for innovative and targeted interventions."
Journal • Oncology
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Huannan Wang; Maocai Yan; Shihao Jin; Zhen Zhang
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