Raloxifene Prevents Chemically-Induced Ferroptotic Neuronal Death In Vitro and In Vivo. (PubMed, Mol Neurobiol) - Oct 2, 2024 - "Ferroptosis, a regulated form of cell death characterized by excessive iron-dependent lipid peroxidation, can be readily induced in cultured cells by chemicals such as erastin and RSL3. In conclusion, this study demonstrates that RAL is a potent inhibitor of PDI and can effectively prevent chemically induced ferroptosis in hippocampal neurons both in vitro and in vivo. These findings offer a novel estrogen receptor-independent mechanism for RAL's neuroprotective actions in animal models and humans."
Journal • Preclinical
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Bao Ting Zhu; Lixi Liao; Ming-Jie Hou; Xiangyu Hao; Yifan Wang; Ying-Hua Wang; Yong Xiao Yang
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