Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

Icariin alleviates cellular injury induced by cardiac ischemia-reperfusion injury by inhibiting IRE1/JNK-induced ferroptosis. (PubMed, Biochem Biophys Res Commun) - Sep 26, 2024 - "Our findings highlight ICA's potential in modulating IRE1/JNK pathway, autophagy, providing a therapeutic avenue for mitigating ferroptosis in myocardial ischemia-reperfusion injury (MIRI)."
Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia • Reperfusion Injury • ATF6 • ERN1 • NCOA4

http://www.ncbi.nlm.nih.gov/pubmed/39321486

Kun Yang; Shilin Tang; Tianyi Ma; Zanrui Zhong

Sep 26, 2024