Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis. (PubMed, Sci Rep) - Sep 6, 2024 - "In the present study, we used ferric ammonium citrate and erastin to evaluate ferroptosis induction effects on two human GBM cell lines, U-251 MG, with proneural characteristics, and T98-G, with a mesenchymal profile...Moreover, using bioinformatic approaches and analysing publicly available datasets from patients' biopsies, we found that GBM with a mesenchymal phenotype showed an up-regulation of several genes involved in antioxidant mechanisms as compared to proneural subtype. Thus, our results suggest that GBM subtypes differently respond to ferroptosis induction, emphasizing the significance of further molecular studies on GBM to better discriminate between various tumor subtypes and progressively move towards personalized therapy."
Journal • Brain Cancer • CNS Tumor • Glioblastoma • Hematological Disorders • Oncology • Solid Tumor
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Alessandro Lavoro; Angela Maria Amorini; Cesarina Giallongo; Daniele Tibullo; Filippo Torrisi; Gaetano Magro; Giacomo Lazzarino; Giuseppe Lazzarino; Lucia Salvatorelli; Massimo Libra; Nunzio Vicario; Rosalba Parenti; Saverio Candido; Sebastiano Giallongo; Simona D'Aprile; Simona Denaro
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