Human adipose mesenchymal stem cell-derived exosomes alleviate fibrosis by restraining ferroptosis in keloids. (PubMed, Front Pharmacol) - Sep 3, 2024 - "To investigate the impact of ferroptosis on keloid fibrosis, Erastin and ferrostatin-1 (fer-1) were utilized to treat keloid fibroblast...We demonstrated a new potential mechanism by which anti-ferroptosis inhibits the progression of keloid fibrosis and identified an ADSC-Exo-based keloid therapeutic strategy. Resisting the occurrence of ferroptosis and the existence of the SLC7A11-GPX4 signaling pathway might serve as a target for ADSC-Exos."
Journal • Fibrosis • Immunology • Metabolic Disorders • GPX4 • SLC7A11
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Jian Yuan; Lijun Hao; Meijia Li; Rong Cheng; Xinyue Chen; Yuan Tian; Zhishan Xu; Zhiyong Diao
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