PET117 promotes ferroptosis in colorectal cancer cells through regulation of mitochondrial metabolism (IDDF 2024) - Aug 22, 2024 - Abstract #IDDF2024-ABS-0263; "Importantly, compared with the control group, loss of PET117 inhibited erastin or RSL3-induced ferroptosis, while overexpression of PET117 in PET117-KO cells increased sensitivity to erastin or RSL3-induced ferroptosis. Our study reveals that PET117 is significantly upregulated in CRC and exerts a pro-ferroptotic effect. PET117 may serve as a potential target for CRC treatment."
Colorectal Cancer • Gastrointestinal Cancer • Metabolic Disorders • Oncology • Solid Tumor
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Qiong Sun; Mengdi Zhang; Jing Han; Xiaolong Guo; Junjun She
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