Real-world effectiveness and safety of cenobamate in children and adolescents with drug-resistant epilepsy: a systematic review, meta-analysis, and meta-regression. (PubMed, Epilepsy Behav) - Oct 21, 2026 - "Approximately six in ten pediatric patients with DRE achieved ≥50 % seizure reduction with cenobamate. However, persistent unexplained heterogeneity and exclusively retrospective evidence limit subgroup-level inference. Prospective individual-patient-data registries with standardized outcome and dosing measures are needed to better define effectiveness, safety, and predictors of response in pediatric populations."
Journal • Real-world evidence • Retrospective data • Review • CNS Disorders • Epilepsy • Pediatrics
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Debopam Samanta; Praveen Kumar Ramani; Puneet Jain
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