Impact of Organ-Specific Severe Immune-Related Adverse Events on Long-Term Survival and Treatment Transitions in Metastatic Renal Cell Carcinoma: A 5-Year Multicenter Multistate Analysis. (PubMed, Cancer Med) - Oct 20, 2026 - "In this exploratory retrospective study, severe non-endocrine irAEs showed an association with early onset and potentially unfavorable clinical outcomes in patients with mRCC receiving ipilimumab plus nivolumab. Given the limited sample size, these findings should be interpreted cautiously and require confirmation in larger independent cohorts."
Adverse events • Journal • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor
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Hiroaki Ikoma; Hiroko Suzuki; Kazumasa Sato; Kengo Kawase; Masayuki Usami; Misato Tomita; Rei Unno; Ryuga Kato; Shuzo Hamamoto; Takahiro Yasui; Takashi Nagai; Taku Naiki; Takuya Sakata; Toshiki Etani; Yohei Tsubouchi; Yoko Furukawa-Hibi; Yoshihiko Tasaki; Yoshihisa Mimura; Yosuke Sugiyama; Yusuke Noda
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