Positioning Cenobamate in the Treatment Algorithm of Focal Epilepsy: Seizure Control and Benefits Beyond Seizures. (PubMed, Neurol Ther) - Oct 17, 2026 - "The most relevant drug-drug interaction is with clobazam, which may have a synergistic efficacy effect and in parallel increases plasma concentrations of clobazam, thereby inducing adverse events. Beyond seizure reduction, an early intervention with CNB may modify the prognosis of epilepsy, reducing the long-term mortality risk, cognitive impairment, or psychiatric disorders. The panel converged on a priority to position CNB as a third-line treatment in the focal epilepsy treatment algorithm owing to its high efficacy, which will probably lead to modification of the long-term global outcomes of people with epilepsy."
Journal • Review • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Epilepsy • Fatigue • Mental Retardation • Psychiatry
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Irene García-Morales; José Maria Serratosa; Juan Jesús Rodriguez-Uranga; Manuel Toledo; Mar Carreño; Vicente Villanueva
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