Sitagliptin attenuates urease-associated phenotypes and potentiates meropenem in multidrug-resistant Gram-negative clinical isolates: a preliminary repurposing study. (PubMed, J Antimicrob Chemother) - Oct 17, 2026 - "In the tested preparations and isolate panel, sitagliptin attenuated urease-associated phenotypes, reduced apparent meropenem-hydrolyzing activity and potentiated meropenem, supporting its further investigation as a potential anti-virulence and antibiotic-adjuvant candidate."
Journal • Infectious Disease
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Afaf Eladl; Hisham A Abbas; Marwa Ibrahim Abd El-Hamid; Nada A Noureldin; Samar S Elbaramawi; Shaimaa I Nazeih
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