Change in clobazam pharmacokinetics after introduction of cenobamate. (PubMed, Epilepsia) - Oct 16, 2026 - "The average combined CLB + N-CLB level after cenobamate titration was 2191 μg/mL, not significantly different from baseline (2358 μg/mL). Although there may be individual variability, a 70%-74% CLB dose reduction may be appropriate to achieve an equivalent combined CLB + N-CLB level."
Journal • PK/PD data • CNS Disorders • Epilepsy
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Bassel W Abou-Khalil; Kevin F Haas; Melissa R Osborn
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