Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies.

seliciclib (CYC202) - Cyclacel, Cedars-Sinai

http://www.ncbi.nlm.nih.gov/pubmed/39149093

Abdul Majeed Abdullah Alayyaf; Abdullah Mohammed Al-Majid; Amira El-Yazbi; Assem Barakat; Marwa M Abu-Serie; Marwa M Shaaban; Matti Haukka; Mohamed S Nafie; Mohamed Teleb; Mohammad Shahidul Islam; Refaah M Al-Jassas

Aug 16, 2024