Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of small interfering RNA therapeutics and interactions with small molecule drugs.

atorvastatin - Generic mfg.

Onpattro (patisiran) - Alnylam, Sanofi

chloroquine phosphate - Generic mfg.

Amvuttra (vutrisiran) - Alnylam

http://www.ncbi.nlm.nih.gov/pubmed/41564596

Beshoy Armanios; Jing Jin; Le Tra Giang Nguyen; Sherouk M Tawfik; Xiao-Bo Zhong

Jan 22, 2026