Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated.

Onpattro (patisiran) - Alnylam, Sanofi

Spikevax (elasomeran) - Moderna

Comirnaty (tozinameran) - Pfizer, BioNTech

http://www.ncbi.nlm.nih.gov/pubmed/41551054

Andrew J Clulow; Angus P R Johnston; Colin W Pouton; Emily H Pilkington; Hee Jung Kang; Wye-Khay Fong; Yujia He

Jan 19, 2026