Selective deletion of the KRAS mutant gene with ADGN-123 and ADGN-121 peptide-RNA nanoparticles: A new strategy to overcome acquired resistance to KRASG12C and KRASG12D small molecule inhibitors

ADGN-123 - Aanastra

Krazati (adagrasib) - BMS

ADGN-121 - Aanastra

Lumakras (sotorasib) - Amgen

MRTX1133 - BMS

G. Divita 1; A. Grunenberger 2; V. Guzman-gonzalez 2; E. Czuba 2; k. Boularache 2; M. Guidetti 3; V. Josserand 3; N. Desai1

Mar 6, 2024