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Osaka, Japan, June 8, 2012—Takeda Pharmaceutical Company Limited (“Takeda”) announced today that it has finalized a contract to transfer TAK-070, which was previously developed by Takeda as a potential treatment of Alzheimer-type dementia, to the National University Corporation, The University of Tokyo (Bunkyo-ku, Tokyo, Japan “The University of Tokyo”). Based on the contract, Takeda shall receive an upfront payment and a certain rate of royalty from the sales generated through the University of Tokyo, if TAK-070 is commercialized. No other economic conditions are disclosed.
TAK-070 was discovered by Takeda, and acts to inhibit the β-secretase enzyme. Amyloid-β-protein is postulated as a fundamental cause of Alzheimer-type dementia, and is produced by the action of β-secretase on Amyloid-β-precursor protein. TAK-070 therefore suppresses the production of amyloid-β protein by inhibiting this β-secretase.
The University of Tokyo Hospital is designated by the Ministry of Health, Labour and Welfare as the base for “the national early/exploratory clinical trial project”. This project aims to conquer dementia and intractable neurological and psychiatric diseases, and it is preparing to build a system that will enable the continuous conduct of clinical studies ranging from early stage clinical trials to POC*1 studies by introducing drug candidates from both home and abroad. TAK-070 will be the first new drug candidate to undergo clinical research at this hospital.
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