Pharmacokinetics, pharmacodynamics, and radiomitigative efficacy of IEPA in a non-human primate model of acute radiation syndrome. (PubMed, Int J Radiat Biol) - May 27, 2026 - "Imidazolyl ethanamide pentandioic acid (IEPA), a novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier...These results indicate that IEPA has the potential to be further investigated as a MCM for ARS. To continue toward a clinical development path, the confirmation of the presented results with a study design adequately powered to assess a drug-mediated survival benefit is needed."
Journal • PK/PD data • Preclinical • Hematological Disorders
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Corinna Asang; Dirk Pleimes; Michael Eibl; Radoslaw Wesolowski; Stella Bähr
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