Betel nut sucking is the earliest recorded evidence for the habitual use of a neuroactive plant drug.

arecoline - Cogent Pharma

http://www.ncbi.nlm.nih.gov/pubmed/42715315

Fakhri; Suryatman; Adam Brumm; Andi Muhammad Saiful; Basran Burhan; Budianto Hakim; Carney D Matheson; Clare Stokes; Delta Bayu Murti; Marlon N R Ririmasse; Melandri Vlok; Michelle C Langley; Pratiwi Yuwono; Roger L Papke; Sofwan Noerwidi

Sep 10, 2026