Modulation of voltage-dependent K+ channel activity by the muscarinic receptor antagonist solifenacin in native coronary arterial smooth muscle cells. (PubMed, Korean J Physiol Pharmacol) - Sep 15, 2026 - "These results indicate that solifenacin targets multiple Shaker-related (Kv1.x) channel subtypes, with Kv1.5 making a substantial contribution to the observed current suppression. Solifenacin inhibits arterial Kv channels in a concentration- and use (inactivated state)-dependent manner by modulating inactivation gating, predominantly involving the Kv1.5 subtype."
Journal
|
|
Daeun Shin; Eun-Taek Han; Hongzoo Park; Hye Ryung Kim; Jin Ryeol An; Jin-Hee Han; Se Jin Lee; Seokhun Jeong; Seungjoo Kim; Sooa Lee; Sunghun Na; Wanjoo Chun; Won Sun Park
|