X-linked hyper-IgM syndrome presenting as severe Pneumocystis pneumonia in a 6-month-old infant: a case report. (PubMed, Front Immunol) - Sep 11, 2026 - "He was treated with mechanical ventilation, trimethoprim-sulfamethoxazole (TMP-SMX), micafungin, corticosteroids, and intravenous immunoglobulin (IVIG), and was discharged after 36 days. Early aggressive management and evaluation for hematopoietic stem cell transplantation are essential to improve outcomes.Serial immunological evaluation is essential in infants with recurrent or opportunistic infections, as persistently low IgA and declining T-cell counts-even when initial screening appears normal-should prompt genetic evaluation for underlying immunodeficiency. Early aggressive management and evaluation for hematopoietic stem cell transplantation are essential to improve outcomes."
IO biomarker • Journal • Bone Marrow Transplantation • Immunology • Infectious Disease • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • Transplantation • CD40LG
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Guoyan Lu; Lijun Zhang; Lulu He; Mengting Li; Xiaoli He; Ying Guo
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