Effect of Age and Age-Defined Menopausal Status on Linaclotide Efficacy and Safety in Adults With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation: Post Hoc Analyses of Phase 2b/3 Studies. (PubMed, Neurogastroenterol Motil) - Sep 8, 2026 - "In this exploratory post hoc analysis, linaclotide was associated with improvements in bowel and abdominal symptoms across age and age-defined menopausal subgroups, with a safety profile consistent with previous studies, suggesting that age and menopausal status did not meaningfully influence treatment outcomes."
Journal • P2/3 data • P2b data • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder
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Alexander C Ford; Darren M Brenner; James Wu; Kyle Staller; Lesley A Houghton; Lin Chang; Niha Yerneni; Paul Feuerstadt; Sally Higgins; Wendy Chen
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