Breakthrough rhino-orbito-cerebral mucormycosis caused by Rhizopus arrhizus during posaconazole prophylaxis after allogeneic hematopoietic stem cell transplantation: a case report and focused literature review. (PubMed, Front Med (Lausanne)) - Sep 10, 2026 - "Additional research-based antifungal susceptibility testing performed during hospitalization using a broth microdilution method in accordance with CLSI M38-Ed3 yielded MICs of 0.25 mg/L for amphotericin B, 0.5 mg/L for posaconazole, and 1 mg/L for isavuconazole. Liposomal amphotericin B and endoscopic surgical debridement were instituted; however, the course was complicated by diagnostic uncertainty, multiple antifungal regimen modifications, persistent hypokalemia during treatment, and eventual discontinuation of active systemic antifungal therapy because of financial constraints. The infection progressed to bilateral visual loss, partial meningeal enhancement with intracranial extension, neurological deterioration, and death 50 days after admission. This case highlights the multifactorial nature of ROCM occurring during mold-active prophylaxis and emphasizes that prophylaxis and negative serum fungal biomarkers should not lower clinical suspicion in high-risk..."
Journal • Review • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin's Lymphoma • Oncology • Ophthalmology • T Cell Non-Hodgkin Lymphoma • Transplantation
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Da-Ping Nie; Hui Ying; Jie Qu; Rui-Hua Li; Shanshan Liang; Shuang Han
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