Lusefi (luseogliflozin) - Taisho
Suglat (ipragliflozin) - Kotobuki, Astellas, Merck (MSD)
Jardiance (empagliflozin) - Eli Lilly, Boehringer Ingelheim
Invokana (canagliflozin) - J&J, Daiichi Sankyo, Tanabe Pharma
Apleway (tofogliflozin) - Kowa, Takeda
Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fournier Gangrene: A Disproportionality Analysis Using the Japanese Adverse Drug Event Report Database. (PubMed, Am J Ther) - Sep 10, 2026 - "All 5 SGLT2 inhibitors were associated with FG, with empagliflozin carrying the highest risk. Male patients exhibited elevated susceptibility. Continuous monitoring throughout treatment is essential. Further clinical trials are warranted to clarify causal relationships." 
Adverse events • Journal • Genetic Disorders • Obesity
http://www.ncbi.nlm.nih.gov/pubmed/42714203
 
Aiping Wang; Gai Li; Guangyuan Xiang; Haitao Zhang; Jin'an Chen; Lei Wang; Leilei Dong; Liyi Li; Tianyuan Wang; Xinjuan Sun
 
Sep 10, 2026
 
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