A primary hepatopancreatic cell platform enables cellular dissection of glucose metabolism and endocrine-metabolic regulation in Litopenaeus vannamei. (PubMed, Front Endocrinol (Lausanne)) - Sep 6, 2026 - "Linsitinib treatment substantially blunted glucose responsiveness and shifted the transcriptional profile toward impaired glucose utilization...Collectively, this study establishes a controllable and expandable primary hepatopancreatic cell platform for dissecting nutrient sensing, glucose metabolic homeostasis, and endocrine-metabolic regulation in L. vannamei. This system provides a valuable cellular tool for crustacean endocrinology and metabolism research and offers a useful framework for future functional studies in economically important crustacean species."
Journal • Endocrine Disorders
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Hu Duan; Jiawei Liu; Lin Song; Su Liu; Xiaowei Song; Yi Gao; Zijie Liu
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