Donor lymphocyte infusion as immune modulation after pediatric allogeneic transplantation. (PubMed, Blood Immunol Cell Ther) - Sep 10, 2026 - "Furthermore, we examine emerging combinations, including DLI with blinatumomab in B-cell acute lymphoblastic leukemia and hypomethylating agents in myeloid malignancies. Finally, we discuss T-cell subset manipulation to mitigate graft-versus-host disease while preserving the graft-versus-leukemia effects. All these data support a modern framework for pediatric DLI that prioritizes early, biology-informed interventions and rational combinations, underscoring the urgent need for pediatric-specific prospective studies."
Journal • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immune Modulation • Immunology • Leukemia • Oncology • Pediatrics • Transplantation
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Dimitrios Filioglou; Emmanuel Katsanis; Richard J Simpson
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