Pre-treatment T cell features and immune-milieu characteristics shape treatment-induced exhaustion and resistance to Blinatumomab in B-cell acute lymphoblastic leukemia. (PubMed, Front Immunol) - Sep 5, 2026 - "These findings indicate that post-Blina CD8+ T-cell exhaustion is associated with resistance and it is shaped by both reduced ZNF683-dependent cytotoxic programming in CD8+ TEM and an immunosuppressive milieu. This provides a rationale for risk stratification based on baseline transcriptional profiling of CD8+ TEM and for combinatorial strategies targeting the suppressive microenvironment."
IO biomarker • Journal • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Hematological Malignancies • Leukemia • Oncology • CD8 • CSF1 • HAVCR2 • LGALS9
|
|
Agnese Petrera; Amelie Muth; Chang-Feng Chu; Christina E Zielinski; Daniel Nixdorf; Francesco Corrado; Giulia Magno; Giulia Rappa; Jan Wulf; Marion Subklewe; Maryam Kazerani; Michael von Bergwelt-Baildon; Michaela Scheurer; Nora Philipp; Tobias Straub; Veit Bücklein; Viktoria Blumenberg
|