A new MRR1 gain-of-function mutation involved in cross-resistance to antifungal agents in the fungal priority pathogen Candida parapsilosis. (PubMed, Med Mycol) - Sep 5, 2026 - "The G982E is a novel Mrr1 gain-of-function mutation driving high-level fluconazole resistance in C. parapsilosis. These findings reinforce the central role of Mrr1 in antifungal resistance, underscore the functional diversity of its mutational landscape, with potential implications for fungal fitness and transcriptional regulation."
Journal • Candidiasis • Infectious Disease
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Alina Marcela-Sabou; Estelle Robert; Florent Morio; Isabelle Ourliac-Garnier; José Rivaldo De Lima; Manon Cadeau; Patrice Le Pape
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