Discovery of a highly selective FLT3-ITD inhibitor with potent antileukemic activity based on 4-(2-fluorophenoxy)pyridine scaffold. (PubMed, Eur J Med Chem) - Sep 3, 2026 - "Mechanistically, 18p suppressed FLT3 autophosphorylation and downstream STAT5, AKT, and ERK signaling more effectively than gilteritinib at equimolar concentrations, and induced potent G1-phase arrest and apoptosis in MOLM-13 cells...Histopathological examination of major organs confirmed an absence of overt toxicity. These findings position 18p as a promising FLT3-ITD inhibitor and provide valuable insights for further development of mutation-selective AML therapeutics."
Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • CASP3 • FLT3 • KIT • PDGFRB • STAT5
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Dan Yang; Dongsheng Zhao; Lei Tang; Lin Li; Qingmei Song; Qingqing Fu; Weike Liao; Weiwei Ouyang; Yiwei Zhang; Yue'e Chai; Yunfeng Wang; Zhongyuan Wang
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