Microbiome Restoration in Fulminant Clostridioides difficile Infection: A Case Series of Fecal Microbiota, Live-jslm for Refractory Disease (ACG 2026) - Aug 29, 2026 - Abstract #P5868; Pres time: Oct 13, 2026; 10:30 AM - 04:00 PM; Location: Exhibit Halls A - D (Level 3); "He improved with oral vancomycin and intravenous metronidazole but deteriorated after transition to fidaxomicin, with worsening abdominal pain, leukocytosis, and imaging concerning for evolving toxic megacolon. The American Gastroenterology Association suggests microbiome restoration in select individuals not responding to guideline directed medical therapy given associated mortality. Prospective studies are needed to define patient selection, timing of standardized microbiome therapies, and long-term outcomes."
Clinical • Acute Kidney Injury • Gastrointestinal Disorder • Infectious Disease • Nephrology • Renal Disease
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Isabel Lopera; MD; Giuseppe Maiocco; MD; Guneet Janda; MD; Sahil Khanna; MBBS; MS
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