Urothelial Carcinoma Presenting as Acute Liver Failure: A Diagnostic Pitfall Mimicking ICI-Induced Hepatotoxicity (ACG 2026) - Aug 29, 2026 - Abstract #P1804; Pres time: Oct 11, 2026; 03:30 PM - 07:00 PM; Location: Exhibit Halls A - D (Level 3); "Case Description/ An 85-year-old male with prostate cancer status post radiation and invasive high-grade urothelial carcinoma treated with Enfortumab vedotin and Pembrolizumab presented with several weeks of generalized weakness, unsteady gait, and unintentional weight loss. Both entities with similar biochemical abnormalities and temporal association with immunotherapy. In patients with advanced malignancy, rapid clinical decline, or steroid-refractory liver injury, clinicians should maintain a low threshold for liver biopsy to establish the diagnosis."
Autoimmune Hepatitis • CNS Disorders • Genito-urinary Cancer • Hepatocellular Cancer • Hepatology • Immunology • Liver Failure • Nephrology • Oncology • Prostate Cancer • Solid Tumor • Urothelial Cancer
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My Nguyen; DO; MS; Ian Fladie; DO; Christopher Naumann; MD
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