SPP1 as a predictive biomarker and therapeutic target in fibrotic (TTS 2026) - Sep 17, 2026 - Pres time: Sep 23, 2026; 08:00 AM - 08:10 AM; Location: Cockle Bay 1; 401; "Therapeutic targeting used ASK8007, an anti-SPP1 monoclonal antibody, delivered via hyaluronic acid-coated lipid nanoparticles in kidney transplant models... This study presents SPP1 as a central mediator of CAD progression, a clinically actionable predictive biomarker, and a promising therapeutic target for precision interventions in kidney transplantation. The findings challenge the conventional immune-centric paradigm, propose a dual epithelial–immune model of fibrosis, and introduce a novel therapeutic delivery strategy for targeted anti-SPP1 therapy."
Biomarker • Chronic Kidney Disease • Fibrosis • Immunology • Inflammatory Arthritis • Nephrology • Rheumatoid Arthritis • CST3 • SPP1
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Zeping Gui1; Zijie Wang1; Min Gu1; Zexin Yang1
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