Multidimensional Symptom Improvement in Adults With Severe Irritable Bowel Syndrome With Constipation (IBS-C) Treated With Linaclotide: A Post Hoc Analysis of Phase 3 Trials (ACG 2026) - Aug 29, 2026 - Abstract #P5351; Pres time: Oct 13, 2026; 10:30 AM - 04:00 PM; Location: Exhibit Halls A - D (Level 3); P3, P3b | "A total of 1651 patients met criteria for severe IBS-C at BL. Demographics and BL symptoms were similar between LIN (n=838) and PBO (n=813) groups ( Table ). LIN vs PBO, respectively, had greater least-squares mean (standard error) improvements from BL in CSBMs/week 2.3 (0.09) vs 0.73 (0.09) and SBMs/week 3.9 (0.12) vs 1.3 (0.12) over 12 weeks ( P < 0.0001)."
Clinical • P3 data • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder
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Kyle Staller MD MPH 1; Anthony J. Lembo MD 2; Danielle D'Achino PharmD 3; James Wu PhD 3; Mena Boules MD 3; Jens J. Kort MD PhD 4; Fang Fang PhD 4; Brooks D. Cash MD 5; Baha Moshiree MD MSc FACG 6; Paul Feuerstadt MD FACG 7
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