Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats. (PubMed, Tissue Cell) - Sep 27, 2026 - "EMPA mitigates MTX-induced neurotoxicity by re-engaging Nrf2/HO-1/GPX4, limiting iron-dependent lipid peroxidation (tissue iron,4-HNE) and dampening PTGS2/ACSL4-linked ferroptosis alongside inflammatory and apoptotic cascades. These findings support EMPA as a potential adjunct to reduce MTX-related cognitive impairment and warrant evaluation in chronic, clinically relevant regimens."
IO biomarker • Journal • Preclinical • Alzheimer's Disease • Cognitive Disorders • Hematological Disorders • Inflammation • ACSL4 • BCL2 • CASP3 • CASP9 • GPX4 • PACERR • PTGS2
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Eman M Embaby; Hasnaa Ali Ebrahim; Hend M Hassan; Mahmoud Hendawy; Mamdouh Eldesoqui; Mohamed Elsherbiny; Mohammad El-Nablaway; Muhammad E Muhammad; Mustafa Shukry; Omnia S Erfan
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