Synthesis, characterization, crystal structures, antitumor activity, and computational study of novel thiosemicarbazone derivatives from thiazol-2/5-carbaldehyde. (PubMed, RSC Adv) - Sep 26, 2026 - "Compounds 3 and 6 showed similar cytotoxicity in comparison to the reference compound (5-fluorouracil). Molecular docking suggested that 3 and 6 engage key PLK1 residues through hydrophobic, hydrogen-bonding, and π-stacking interactions while BI2536 provides a broader and more established interaction profile. These findings demonstrate that compounds 3 and 6 have the potential to be considered as promising lead compounds for further investigation."
Journal • Breast Cancer • Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Genito-urinary Cancer • Melanoma • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Small Intestinal Carcinoma • Solid Tumor • PLK1
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Abraham Vaisberg; Christian Jänke; Evgenia Spodine; Fernando Carrasco; Harald Krautscheid; Lothar Beyer; Maik Icker; Osvaldo Yañez; Wilfredo Hernández
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