BASAL RELEASE OF 6-CYANODOPAMINE AND 6-NITRODOPAMINE FROM RAT ISOLATED AORTA AND THEIR ROLE IN VASCULAR RELAXATION. (PubMed, Eur J Pharmacol) - Sep 20, 2026 - "Vascular reactivity was assessed in U-46619-precontracted rings with intact or removed endothelium and after pharmacological inhibition with Nω-nitro-L-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), indomethacin, SQ-22536, SCH-23390, and haloperidol...SQ-22536 also attenuated forskolin- and iloprost-induced relaxation, supporting involvement of adenylyl cyclase/cAMP signaling in 6-CYD responses...Rat thoracic aorta basally releases 6-CYD and 6-ND, and although both act as potent vasodilators, they have distinct mechanisms of action. These findings shed new light on mechanisms by which the vascular endothelium regulates vascular tone."
Journal • Preclinical • Cardiovascular • Hypertension
|
|
Albert Ferro; Andre Almeida Schenka; Antonio Tiago Lima; Caroline Fernanda Sanches Dal Pozzo; Edson Antunes; Eric Xavier Dos Santos; Friedrich Nietzsche Xavier Cisota; George Said; Gilberto De Nucci; José Britto-Júnior; Larryn W Peterson; Valéria Barbosa de Souza
|