Esomeprazole inhibits EGF-induced invasion and migration of gastric cancer cells. (PubMed, PeerJ) - Sep 16, 2026 - "This study aims to investigate the inhibitory effect of ESO on EGF-induced invasion and migration of gastric cancer cells, and its relationship with the EGFR/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway. The combination of ESO and afatinib (an irreversible EGFR inhibitor) led to a more pronounced reduction in cell viability, invasion, migration, and protein expression compared to either treatment alone. ESO inhibits EGF-induced invasion and migration in GC cells potentially via the EGFR/AKT/mTOR pathway, offering a potential new strategy for GC treatment."
Journal • Gastric Cancer • Oncology • Solid Tumor • CDH2 • MMP2 • MMP9 • VIM
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Fangfang Huang; Hongqiao Zhang; Jinfeng Du; Mengru Tian; Qiangqiang Lv; Xiufeng Chu; Xuanruo Zhang; ZiSen Zhang
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