Twenty-four-hour lactate dynamics and adverse in-hospital outcomes in acute pulmonary embolism treated with systemic thrombolysis: A retrospective cohort study. (PubMed, Phlebology) - Sep 30, 2026 - "We examined the association between 24-h lactate dynamics and an adverse in-hospital clinical course.MethodsIn this retrospective single-centre cohort, 40 consecutive adults who received systemic alteplase for acute PE (2024-2025) were analysed...The association of Δ lactate persisted after adjustment for age and showed minimal optimism on bootstrap internal validation.ConclusionsIn this selected cohort receiving systemic thrombolysis, admission lactate did not reproduce the discrimination reported in broader PE populations, whereas 24-h lactate dynamics showed a stronger association with the adverse in-hospital course. Δ lactate should be regarded as a marker of concurrent severity rather than a predictor of treatment response; the candidate thresholds are hypothesis-generating and require prospective validation."
Journal • Retrospective data • Cardiovascular • Pulmonary Embolism • Respiratory Diseases
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Orkun Eray Terzi; Seyhan Dülger
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