Enhancing Curcumin Performance via PVP K30 Solid Dispersion: Synergistic Potential in Combination with Conventional Chemotherapeutic Agents in NSCLC Cells. (PubMed, AAPS PharmSciTech) - Sep 13, 2026 - "This study aimed to optimize a solid dispersion of CUR with polyvinylpyrrolidone K30 (PVP K30) to enhance its biopharmaceutical properties and to evaluate its ability to enhance cytotoxic activity of conventional chemotherapeutic drugs (Afatinib, Cisplatin, and Metformin) in A549 NSCLC cells. Analysis of the combination index (CI) revealed synergistic interactions, as values less than 1 (CI < 1) were obtained for all combinations. These findings demonstrate that the use of solid dispersions significantly improves the solubility of CUR, potentially offering a promising strategy for enhancing the in vitro cytotoxic activity of conventional chemotherapeutic agents."
Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor
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Adriana Tejeda-Cruz; Carla O Contreras-Ochoa; Daniel Hernandez-Patlan; Elvia A Morales Hipólito; Hugo Cortés Martínez; Javier J Espinosa-Aguirre; Marisol Mir-Garcia; Raquel López-Arellano; Sandra L Hernández-Ojeda
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