Safety and efficacy of tenecteplase versus alteplase for acute ischemic stroke in a real-world patient population. (PubMed, Am J Emerg Med) - Sep 10, 2026 - "There were no statistically significant differences in safety or efficacy between TNK and alteplase for AIS. These results provide real-world experience especially in a large, older patient population, with relatively minor stroke. Type II error may limit findings. Research is needed to identify patient, stroke, or fibrinolytic agent related factors that may increase bleeding occurrence."
Journal • Real-world evidence • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Ischemic stroke
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Aaron Weaver; Ann Leonhardt-Caprio; Chistine M Groth; Courtney M C Jones; Elizabeth Uttaro; Nicole M Acquisto; Rachel Bishop; Stephanie Toole; Trevor Spalding
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