Pharmacological activation of dopamine receptor D1 attenuates TGF-β-induced epithelial-mesenchymal transition in A549 and BEAS-2B cells. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - Sep 10, 2026 - "Dopamine analogues, DRD1 agonists, and the DRD1 antagonist SCH23390 were used to evaluate the role of DRD1...In these pulmonary epithelial cell-line models, DRD1 agonist treatment attenuated TGF-β-induced EMT-related changes and was associated with restoration of cAMP/PKA signaling. These in vitro findings identify DRD1 signaling as a candidate mechanism for further preclinical study; confirmation in primary cells, epithelial-fibroblast systems, and animal models is required before therapeutic relevance to pulmonary fibrosis can be inferred."
Journal • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • CDH1 • SNAI1 • TGFB1 • VIM • ZEB1
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Chuanguo Liu; Hong Guo; Jiang Zhu; Kai Gong; Lingyu Li; Mengzhen Xu; Qingjun Zhu; Tianying Sun; Yan Liu; Yingying Zhang; Zhiyang Li
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