Tizanidine Withdrawal Syndrome: Clinical Manifestations and Management Strategies. Case Series. (PubMed, J Pain Palliat Care Pharmacother) - Sep 9, 2026 - "Case 1 was a 24 year old female admitted with empagliflozin induced diabetic ketoacidosis who experienced hypertensive crisis and tachycardia following abrupt cessation of chronic high dose tizanidine...Case 3 was a 29 year old female with recurrent pancreatitis, resistant hypertension, and an adrenal incidentaloma who presented with severe hypertension and tremors after discontinuing both tizanidine and diazepam...Case 4 was a 42 year old male with asthma, hypertension, anxiety disorder, bariatric surgery, methamphetamine use, and more than ten prior admissions specifically for tizanidine withdrawal, who presented with palpitations, tremors, vomiting, and hypertensive crisis after abrupt dose reduction...Patient education on avoiding abrupt discontinuation is essential, particularly for individuals with psychiatric comorbidities or prior withdrawal episodes. Awareness of this underrecognized syndrome is critical to prevent misdiagnosis and ensure safe..."
Journal • Asthma • Cardiovascular • CNS Disorders • Crohn's disease • Gastroenterology • Hypertension • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Movement Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Pancreatitis • Psychiatry • Pulmonary Disease • Respiratory Diseases
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Emad AlAttar; Farook AlRawi; Samaira Rafique
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