TNKASE (tenecteplase) - Roche, Boehringer Ingelheim
Activase (alteplase) - Roche, Boehringer Ingelheim, Kyowa Kirin, Tanabe Pharma
Extending the Treatment Window for Intravenous Thrombolysis in Acute Ischemic Stroke: An Updated Systematic Review and Meta-Analysis. (PubMed, Neurol Clin Pract) - Sep 12, 2026 - "Among patients selected based on imaging, 4.5-24 hours after stroke onset/LKW, IVT improves outcomes despite an increased risk of sICH. TNK showed similar efficacy to alteplase, with a possible lower risk of sICH; however, direct comparisons in future trials are needed." 
Clinical • Journal • Retrospective data • Review • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Ischemic stroke
http://www.ncbi.nlm.nih.gov/pubmed/42727034
 
Ali Moradi; Amir Ghabousian; Amir Moradi; Azeem Latib; Fady Iskander; Kaveh Hosseini; Kimia Najafi; Mohammadreza Alinejadfard; Preethi Ramchand; Soheil Rahmati; Toshiki Kuno; Yasaman Zarinfar
 
Sep 12, 2026
 
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